INDICATED CLAIMS:

·         Helps to maintain and support cardiovascular health.

GENERAL INFORMATION

Coenzyme Q₁₀ or CoQ₁₀ belongs to a family of substances called ubiquinones. Ubiquinones, also known as coenzymes Q and mitoquinones, are lipophilic, water-insoluble sub­stances involved in electron transport and energy production in mitochondria. The basic structure of ubiquinones consists of a benzoquinone "head^" and a terpinoid "tail.^" The "head" structure participates in the redox activity of the electron transport chain. The major difference among the various coenzymes Q is in the number of isoprenoid units (5-carbon structures) in the "tail.^" Coenzymes Q contain one to 12 isoprenoid units in the "tail"; 10 isoprenoid units are common in animals.

Coenzymes Q occur in the majority of aerobic organisms, from bacteria to plants and animals. Coenzyme Q₁₀ is also known as Coenzyme Q (50), CoQ₁₀, and CoQ (50), ubiquinone (50), ubiquinol- 10 and ubidecarer­one. Chemically, CoQ₁₀ is known as 2, 3-dimethyoxy-5­methyl-6-decaprenyl-1, 4-benzoquinone.

MECHANISM OF ACTION

CoQ_I0 has antioxidant activity in mitochondria and cellular membranes, protecting against per oxidation of lipid mem­branes. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.

CoQ₁₀ is biosynthesized in the body and shares a common synthetic pathway with cholesterol. CoQ₁₀ levels decrease with aging in humans. Why this occurs is not known but may be due to decreased synthesis and/or increased lipid per oxidation which occurs with aging.

PHARMACOKINETICS:

CoQ₁₀ is absorbed from the small intestine into the lymphatics; from there it enters the blood. Absorption of CoQ₁₀ is poor. Well over 60% of an oral dose is excreted in the feces. Furthermore, absorption of CoQ₁₀ is highly variable and depends not only on food intake but also on the amount of lipids present in the food. Absorption is lower on an empty stomach and greater when taken with food of high lipid content. In the blood, CoQ₁₀ is partitioned into the various lipoprotein particles, including VLDL, LDL and HDL.It takes about three weeks of daily dosing with CoQ₁₀ to reach maximal serum concentrations, which then plateau with continuous daily dosing. CoQ₁₀ is distributed to the various tissues of the body and is able to enter the brain. The main elimination of CoQ₁₀ occurs via bile.

NUTRALIFE NUCARD 30 Co Q10  (Coenzyme Q 10) 30 mg Capsule

Product information:

Available as 100 capsules

Each capsule contains: Coenzyme Q₁₀ 30mg

Non-medicinal ingredients:  Microcrystalline cellulose, Magnesium Stearate, Dicalcium phosphates dehydrate or Stearate, colloidal Silicon.

Directions for use: adult: take 1 capsule 1 to 3 times daily with meals.

Benefits:

·         Helps to maintain and support cardiovascular health.

·         Plays a role in energy production

·         Helps to reduce free radical damage in the body

·         Protects cells from premature aging

·         Medium potency ideal for low-dose statin use, anti-aging, energy boost

·         Supports healthy CoQ₁₀ levels for patients prescribed statin drugs

CONTRAINDICATIONS

No Known hypersensitivity to a CoQ₁₀-containing product.

PRECAUTIONS:

There is one report of CoQ₁₀ decreasing the effectiveness of warfarin. Those taking warfarin should be aware of this possibility. Because of lack of long-term safety studies, pregnant women and nursing mothers should avoid CoQ₁₀ supplements.

Clinical reports from Japan suggest that supplemental CoQ₁₀ may improve beta-cell function and glycemic control in type II diabetics. CoQ₁₀ does not appear to improve glycemic control in type I diabetics. Diabetics should be made aware of this possibility, and those diabetics who do use supple­mental CoQ₁₀ should determine by appropriate monitoring if they need to make any adjustments in their diabetic medications.            -

ADVERSE REACTIONS

Mild gastrointestinal symptoms such as nausea, diarrhea and epigastric distress have been reported, particularly with higher doses (200 milligrams or more daily).

INTERACTIONS:

DRUGS

Antidiabetic predications: CoQ₁₀ may improve glycemic control in some type II diabetics. If this were to occur, antidiabetic medications might need appropriate adjusting.

Bela Mockers: Some beta blockers, in particular propanolol, have been reported to inhibit some CoQ₁₀-dependent enzymes

Doxorubicin: CoQ₁₀ may help ameliorate the cardio toxicity of doxorubicin.

Stations: CoQ₁₀ and cholesterol share the same metabolic pathways. Inhibition of the enzyme 3-hydroxyl-3-methylglu­tonyl coenzyme A (HMG-CoA) reductase would be expected to decrease CoQ₁₀ levels. The statin drugs lovastatin, simvastatin and pravastatin are known to decrease CoQ₁₀ levels in humans. It is likely that all statins have this effect.

DIETARY SUPPLEMENTS:

Alpha-Tocopherol: Elevation in CoQ₁₀ levels in mitochon­dria by dietary supplementation is linked to a corresponding rise in ot-tocopherol content.

FOOD

Piperine: Piperine, found in black pepper, may increase plasma levels of CoQ_10.